Pre- and apnoeic high-flow oxygenation for rapid sequence intubation in the emergency department (the Pre-AeRATE trial): A multicentre randomised controlled trial – Annals Singapore

Critically ill patients in the emergency department (ED) have shorter safe apnoea times due to physiological distress from decreased cardiac output, increased shunting and reduced pulmonary reserves.1 Hypoxia is a commonly encountered adverse event during rapid sequence intubation (RSI)2 and is associated with cardiac arrest, neurological injury and death.3 Therefore, there is significant interest in
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