Dr Peter Sherren, currently working with Master Cliff Reid’s mob in Greater Sydney Area HEMS, sent me this case presentation he wrote on angioedema. Its a great little summary of key issues…and a good preface to the next podcast where Scott and I tackle the topic.
thanks for sharing Peter!
Minh
ketaminh
ntrueger
Yen Chow
Thanks Fellas
Any experience with Icatibant – a selective bradykinin B2 receptor antagonist?
3ml / 30mg subcut injection approved for use in hereditary angioedema (see http://www.australianprescriber.com/magazine/33/6/193/8/new-drugs-944/icatibant) but case series suggest success in ACE-inhibitor related angioedema (http://resusme.em.extrememember.com/?p=2656).
Cliff
Hi Scott! In my retrieval area, there is a family with hereditary angioedema and we have gained experience in treating it with icatibant as well as C14Q esterase concentrate, even tranexamic acid for mild exarcebations. If clinical angioedema was unresponsive to a reasonable dose of adrenaline, and strong suspiscion of bradykinin induced pathophysiology i.e ACEI recently introduced, then absolutely I would give icatibant. On Twitterverse a month ago, a Brit doc commented he had used it in ED in ACEI angioedema case to good effect.