Here is the article abstract
Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
What does this add to the evidence base for ketamine as an antidepressant?
Previous studies have used inactive placebo ( saline) to compare ketamine with. A clear criticism of this is that its quite easy to tell difference between psychoactive drug and saline by both the patient recipient and the study researcher!
This optimised study design used midazolam vs ketamine infusion in treatment resistant depressed patients.
It still showed a rapid significant improvement in depression scores with ketamine, compared with midazolam.
Imagine in the near future, treating a suicidal depressed patient in the ED with a single infusion of ketamine and then discharging this patient home on intranasal ketamine maintenance with outpatient mental health team review.
the evidence base builds and we get closer each time to such a future!