Kath Maitland, the author of the FEAST study, talks about where we go now with fluids in kids, following FEAST
Source: Fluids and Kids: What Now?
Prehospital and Retrieval Medicine – THE PHARM dedicated to the memory of Dr John Hinds
In memory of Dr John Hinds
Prehospital and Retrieval Medicine - THE PHARM dedicated to the memory of Dr John Hinds 
Reblogged this on MEDEST and commented:
The only controlled trial of fluid resuscitation, Fluid Expansion as Supportive Therapy (FEAST), involving 3141 African children with severe febrile illness, including large groups with sepsis and malaria, called into question aggressive fluid resuscitation, demonstrating excess mortality in both bolus arms (albumin and saline) compared to no-bolus control, relative risk of morality in bolus versus control was 1.45 (1.13-1.86, p=0.003)
Four years have elapsed since the publication of FEAST, yet World Health Organization continues to recommend fluid boluses for children managed in resource-poor hospitals, where there is no access to intensive care. In Africa alone, where one in 10 febrile child admissions present with shock, we have estimated that the current guidelines, if fully implemented, will result in ~5,600 and 33,000 excess deaths each year per million hospital admissions treated for shock.